A multiparticulate dosage form taken at night (bedtime) that delivers drug prior to and during “morning surge” activities will prove useful to treat circadian disorder hypertension. The purpose of the study was to develop pulsatile release multiparticulate dosage form. Carvedilol is a non-selective β-adrenergic blocking agent with α adrenergic blocking activity, used for the treatment of hypertension. In this study, the drug loaded nonpareil seeds were coated with a pH-sensitive Acrycoat L100 and Acrycoat S100 polymers to obtain two population of pellets to achieve drug release with a specific lag time and the effect of weight gain of polymer on lag time was investigated. The formulated pellets were characterized for friability, SEM studies, in vitro dissolution studies and micromeritic properties. The pellets were spherical in shape with smooth texture. The drug loaded pellets coated with Acrycoat L100, with 5% weight gain and the drug loaded pellets coated with Acrycoat S100, with 7.5% weight gain was found to be optimum with desired lag time. The release of the drug after a lag time consistent with requirement for chronotherapeutics was achieved with developed formulation.
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